Description
Weight Management Treatment
Wegovy® tablets is indicated as an adjunct to a reduced-calorie diet and increased physical activity for weight management, including
weight loss and weight maintenance, in adults with an initial Body Mass Index (BMI) of:
- ≥30 kg/m2 (obesity), or
- ≥27 kg/m2 to <30 kg/m2 (overweight) in the presence of at least one weight-related comorbidity.
Wegovy® pill is a once daily GLP 1 analogue oral treatment designed to support weight management that may fit easily into everyday life for some people living with obesity or overweight.
- The only peptide-based GLP-1 pill for weight management
- Contains the active ingredient semaglutide, a GLP-1 analogue with 94% sequence homology to human GLP-1, that helps regulate appetite and calorie intake
- Helps people feel fuller, less hungry, and more in control of cravings
Wegovy® has been used and trusted by millions of people worldwide and studied in ~13,000 people with overweight or obesity in clinical trials
SNAC technology is what makes Wegovy® pill possible:
- Included in every Wegovy® pill is SNAC (sodium N-(8-[2-hydroxybenzoyl] amino) caprylate), a molecule that enables Wegovy® to be taken orally in pill form
- SNAC forms a temporary protective environment for semaglutide in the stomach, preventing degradation and facilitating its absorption into the bloodstream
Results:
Over 64 weeks, in addition to a reduced-calorie diet and increased physical activity, patients taking Wegovy® 25 mg once daily tablet achieved: mean weight loss 14-17% (15-18kg weight loss vs 2-3 kg with placebo)
Side Effects
Most common adverse reactions:
- Very common (≥1/10): Headache, vomiting, diarrhoea, constipation, dyspepsia, nausea, abdominal pain, fatigue
- Common (≥1/100 to <1/10): Hypoglycaemia in patients with type 2 diabetes, dizziness, dysaesthesia, dysgeusia, diabetic
retinopathy in patients with type 2 diabetes, gastritis, gastrooesophageal reflux disease, eructation, flatulence, abdominal distension, cholelithiasis, hair loss
Demonstrated tolerability:
- The gastrointestinal tolerability of Wegovy® 25 mg once-daily tablet in the OASIS 4 trial was consistent with that of existing GLP-1 class of medications
- Most frequently reported adverse events in Wegovy® trials were gastrointestinal disorders, including nausea, diarrhoea, constipation, and vomiting. Most of these events were mild to moderate and transient.
What should I know about nausea (feeling sick)?
Like all medicines, Wegovy® can cause side effects, although not everybody gets them. Feeling sick (nausea) is a very common side effect of Wegovy®, meaning it can affect more than 1 in 10 people. It usually goes away over time. You should speak to your treatment provider if you are struggling with nausea.
How can I manage nausea (feeling sick)?
If you can, the NHS recommends avoiding:
- Hot, fried, greasy or strong-smelling foods
- Eating too quickly
- Drinking a lot while you’re eating
If you can, the NHS recommends trying:
- Smaller portions of food
- Ginger tea and foods that contain ginger
- Regular sips of cold drinks
- Eating slowly and staying upright after finishing your meal
- Keep your mind busy – distract yourself with something you enjoy, such as watching a film or listening to a podcast.
- Get fresh air – breathe in some fresh air by opening a window or spending time outside
Reporting side effects
This medicine is subject to additional monitoring. This will allow quick identification of new safety information promptly. You can help by reporting any side effects you may get.
See https :// yellowcard.mhra.gov.uk/ for how to report side effects. If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. Side effects should also be reported to Novo Nordisk Limited (Telephone Novo Nordisk Customer Care Centre 0800 023 2573). Calls may be monitored for training purposes. By reporting side effects, you can help provide more information on the safety of this medicine.
For a full list of side effects, warnings and precautions, please read the Patient Information leaflet. You can find the Wegovy® Patient Information Leaflet in the box with your medicine.
Patient Information Leaflet
Please see HERE for the Patient Information Leaflet
Additional Info
Do not use Wegovy if you are pregnant, trying to conceive, or breastfeeding.
Tell us before starting if you have or have had:
Pancreatitis or unexplained severe abdominal pain (especially with vomiting)
Gallbladder problems (e.g., gallstones) or yellowing of the skin/eyesSignificant gastro-intestinal disease
Kidney or liver problems
Type 2 diabetes with a history of diabetic retinopathy (your prescriber may tailor advice)
Personal or family history of medullary thyroid carcinoma (MTC) and Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
We will also review all your current medicines and supplements. Semaglutide can delay stomach emptying, which may influence how quickly some tablets are absorbed; we’ll advise if anything needs timing adjustments.
Interactions & monitoring
Tell us if you take diabetes medicines (including insulin or sulfonylureas)—your prescriber may advise extra monitoring for low blood sugar.
Share all prescription, OTC, and herbal products you use.
We’ll suggest simple self-checks: weekly weight, waist measure, side-effect tracker, plus messages at key titration steps.
How to store Wegovy®
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the blister and carton after ‘EXP’. The expiry date refers to the last day of that month.
Store in the original package in order to protect from light and moisture. This medicine does not require any special temperature storage conditions.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
When to contact us or seek urgent help
Severe, persistent abdominal pain (with or without vomiting)
Signs of dehydration from ongoing vomiting/diarrhoea
Possible allergic reaction (wheezing, facial swelling, rash with breathing difficulty)
Side effects that don’t settle or interfere with daily life
Directions
Always take this medicine exactly as your prescriber has directed.
How much to take
Your treatment will start at a low dose which will be gradually increased over 4 months of treatment.
• The starting dose is one 1.5 mg tablet once a day for one month.
• Your doctor will instruct you to gradually increase your dose every month until you reach the recommended dose of 25 mg once daily.
• Once you reach the recommended dose of 25 mg, do not increase this dose further.
Usually, you will be told to follow as below:
– Month 1: initiate treatment with 1.5 mg once daily.
– Month 2: increase the dose to 4 mg once daily.
– Month 3: increase the dose to 9 mg once daily.
– Month 4 and onward: maintain the dose at 25 mg once daily.
Your prescriber will assess your treatment on a regular basis. You should not take two tablets to get the effect of a higher dose.
Taking this medicine
• Take your wegovy® tablet on an empty stomach after a recommended fasting period of at least 8 hours.
• Swallow your wegovy® tablet whole with a sip of water (up to 120 mL). Do not split, crush or chew the tablet, as it is not known if it affects absorption of semaglutide.
• After taking your wegovy® tablet wait at least 30 minutes before eating or drinking or taking other oral medicines. Waiting less than 30 minutes lowers the absorption of semaglutide.
People with type 2 diabetes
Tell your prescriber if you have type 2 diabetes. Your prescriber may adjust the dose of your diabetes medicines to prevent you from getting low blood sugar.
If you take more wegovy® than you should
Talk to your prescriber straight away. You may get side effects such as feeling sick (nausea).
If you forget to take wegovy®
If you forget to take a dose, skip the missed dose and just take your normal dose the next day.
If you stop taking wegovy®
Do not stop using this medicine without talking to your prescriber. If you have any further questions on the use of this medicine, please get in touch with our team so we can assist you.
FAQs
No FAQs available for this product.
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